The 2025 Toyko Series wraps up when the Los Angeles Dodgers (1-0) and the Chicago Cubs (0-1) meet up on Wednesday. The Dodgers started things off the same way the defending champions left off last season, defeating Chicago 4-1 in the first contest of the campaign. Roki Sasaki will be making his debut for the Dodgers. On the flip side, the Cubs have Justin Steele (1-1, 9.35 ERA) taking the mound. They finished the regular season with a 98-64 record, while the Cubs went 83-79.
First pitch from the Tokyo Dome is set for 6:10 a.m. ET. The Dodgers have won 17 of the past 24 meetings with the Cubs. Los Angeles is a -151 favorite on the money line (risk $151 to win $100) in the latest Dodgers vs. Cubs odds from SportsLine consensus, while the total number of runs Vegas thinks will be scored, or the over/under, is 8. Before making any Cubs vs. Dodgers picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 32-17 roll on top-rated run-line betting picks (+699) that dates back to 2023. Anybody following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has set its sights on Dodgers vs. Cubs and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several MLB odds and betting lines for Dodgers vs. Cubs:
- Dodgers vs. Cubs money line: Los Angeles -151, Chicago +127
- Dodgers vs. Cubs over-under: 8 runs
- Dodgers vs. Cubs run line: Los Angeles -1.5 (+110)
- Dodgers vs. Cubs picks: See picks at SportsLine
- Dodgers vs. Cubs streaming: FuboTV (Try for free)
Why the Dodgers can cover
Designated hitter Shohei Ohtani continues to dominate at the plate. In his first season with the Dodgers, Ohtani hit .310 with 54 home runs and 130 RBI. In addition, he smashed 38 doubles and 134 runs scored. Ohtani picked up right where he left off in the opener. In Tuesday’s win over Chicago, he went 2-of-5 with a double and two runs scored.
Left fielder Teoscar Hernandez is another powerful bat in the lineup. Hernandez has great playe coverage that allows him to push the ball into the gaps with ease. In 2024, the 32-year-old hit .272 with 33 home runs, 99 RBI, 32 doubles and 160 hits. In the opener against the Cubs, he went 1-of-4 with one RBI and one run scored. See which team to back at SportsLine.
Why the Cubs can cover
Left fielder Ian Happ has been one of Chicago’s best players for the past nine years. He has sound plate discipline with the power to drive the ball into the gaps. In 2024, he led the team in home runs (25) and RBI (86) along with 34 doubles. Over 20 career games against the Dodgers, Happ has registered 18 hits, six RBI and eight runs scored.
Right fielder Seiya Suzuki is another strong hitter. Suzuki is able to generate consistent contact with the strength to create extra-base hits. Last season for Chicago, the 30-year-old had a team-high .283 batting average with 21 home runs and 73 RBI. He’s notched 17 hits, two home runs, 12 RBI and nine runs scored in 20 career games against Los Angeles. See which team to back at SportsLine.
How to make Dodgers vs. Cubs picks
SportsLine’s model is leaning Over on the total and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins Dodgers vs. Cubs on Wednesday, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.
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