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Mariners vs Reds Prediction: Odds, recent stats, trends, and best bets for July 21

The Mariners (51-50) shut out the Reds (45-54), 7-0, to win the series opener. Seattle has won three straight versus Cincinnati dating back to last season.

Seattle is hot with three straight wins and a 3-1 record since the break. The Mariners entered the break with a 1-5 record over their final six games. Seattle has outscored its opponents 18-6 during their winning streak and now taken control of the AL West lead by half-a-game over Houston.

Cincinnati will toss Chase Burns on the mound and he’s been money for the Reds. Burns is 11-1 on the year, but Cincinnati is 14-4 in his 18 starts and won six consecutive. Cincinnati was shut out last night, but scored 18 runs over the three previous games.

Let’s dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Reds at Mariners

  • Date: Tuesday, July 21, 2026
  • Time: 9:40 PM EST
  • Site: T-Mobile Park
  • City: Seattle, WA
  • Network/Streaming: MLB TV

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Reds at the Mariners

The latest odds as of Tuesday:

  • Moneyline: Cincinnati Reds (+101), Seattle Mariners (-131)
  • Spread: Mariners +1.5 (-207), Reds -1.5 (+170)
  • Total: 7.5

Probable starting pitchers for Reds at Mariners

  • Tuesday’s pitching matchup (July 21): Luis Castillo vs. Chase Burns
  • Mariners: Luis Castillo

2026 stats: 87.2 IP, 3-8, 4.93 ERA, 1.37 WHIP, 81 K, 28 BB

2026 Stats: 102.2 IP, 11-1, 2.54 ERA, 1.11 WHIP, 118 Ks, 37 BB

Who’s Hot? Who’s Not

  • The Reds’ Sal Stewart is hitting .251 with 95 hits, 20 home runs and 70 RBI over 379 at-bats
  • The Reds’ Eugenio Suarez is hitting .208 with 53 hits and 101 strikeouts over 255 at-bats
  • The Mariners’ Randy Arozarena is hitting .284 with 96 hits, 11 home runs, and 45 RBI over 338 at-bats
  • The Mariners’ JP Crawford is hitting .215 with 63 hits and 70 strikeouts over 293 at-bats

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Reds at Mariners

  • Seattle is 40-61 ATS, ranking second-worst
  • Cincinnati is 52-47 ATS
  • Seattle is 49-46-6 to the Over
  • Cincinnati is 56-42-1 to the Over, ranking fifth-best
  • Seattle is 21-30 ATS at home, ranking fifth-worst
  • Cincinnati is 28-21 ATS on the road, ranking third-best

Expert picks & predictions for tonight’s game between the Mariners and the Reds

Rotoworld Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Mariners and the Reds:

  • Moneyline: NBC Sports Bet is recommending a play on the Mariners on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Mariners at +1.5.
  • Total: NBC Sports Bet is recommending a play on the Over on the Game Total of 7.5

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Trysta Krick (@Trysta_Krick)



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