St. Louis (65-62) and Cincinnati (60-66) meet for the fourth game of their five-game series. St. Louis is up 2-1 thus far after a 3-0 win on Tuesday. Entering this matchup, the Reds are 1-4 over the last five games, while the Cardinals are 4-1 in that same span.
The Cardinals find themselves 3.0 games back of the final. NL Wild Card spot trailing the Cubs, Phillies, Padres, and Diamondbacks. St. Louis is hitting .254 in August (10th) with the seventh-most runs scored (81) over 17 games. The pitching rotation ranks second in ERA (2.94), fifth in WHIP (1.18), and fourth in OBA (.224).
Chase Burns takes the mound for Cincinnati as he sports the second-most wins in baseball at 14. The Reds are 17-6 when Burns pitches and won nine of his last 11 starts. In August, the Reds pitching staff owns the 22nd-ranked ERA (4.53), while the offense ranks dead-last in batting average (.193).
Let’s dive into tonight’s matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Cardinals at Reds
- Date: Wednesday, August 19, 2026
- Time: 6:40 PM EST
- Site: Great American Ball Park
- City: Cincinnati, OH
- Network/Streaming: MLB TV
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Odds for the Cardinals at the Reds
The latest odds as of Wednesday:
- Moneyline: St. Louis Cardinals (+131), Cincinnati Reds (-140)
- Spread: Cardinals +1.5 (-182), Reds-1.5 (+150)
- Total: 8.5
Probable starting pitchers for Cardinals at Reds
- Wednesday’s pitching matchup (August 19): Chase Burns vs Matthew Liberatore
- Cardinals: Matthew Liberatore
2026 stats: 119.0 IP, 5-10, 5.07 ERA, 1.48 WHIP, 116 K, 44 BB
2026 Stats: 131.0 IP, 14-2, 2.47 ERA, 1.09 WHIP, 151 K, 46 BB
Who’s Hot? Who’s Not
- Jordan Walker is hitting .344 in August (21/61) with nine RBI
- Alec Burleson is hitting .333 in August (21/53) with six home runs and 21 RBI
- JJ Wetherholt is hitting .169 in August (10/59) with 14 walks and 11 strikeouts
- Sal Stewart is hitting .277 in August (18/65) with three home runs and seven RBI
- Elly De La Cruz is hitting .143 in August (9/63) with nine walks, nine RBI, and 21 strikeouts
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Top betting trends & insights to know ahead of Cardinals at Reds
- St. Louis is 69-58 ATS, ranking fifth-best
- Cincinnati is 65-61 ATS
- St. Louis is 70-50-7 to the Under, ranking second-best
- Cincinnati is 65-50-2 to the Over, ranking eighth-best
- St. Louis is 34-27 ATS on the road, ranking eighth-best
- Cincinnati is 31-35 ATS at home, ranking ninth-worst
Expert picks & predictions for tonight’s game between the Cardinals and the Reds
Rotoworld Bet Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Cardinals and the Reds:
- Moneyline: NBC Sports Bet is recommending a play on the Reds on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Reds at -1.5.
- Total: NBC Sports Bet is recommending a play on the Under on the Game Total of 8.5
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