The San Francisco Giants (10-13) took Game 1 of its series, 3-1, versus the Los Angeles Dodgers (16-7). Los Angeles is now 1-3 over the last four games.
San Francisco is now 4-1 in the past five games and heating up. The Giants are batting .278 over the last seven days, which ranks fifth-best and the pitching staff fourth with a 2.49 ERA. San Francisco has outscored its opponents 23-15 over the last five games.
Los Angeles still ranks atop of the MLB in batting average (.298) over the last five games despite being 2-3 in that span. The Dodgers amid their worst losing skid of the season and a chance for their first series loss. Los Angeles is 2-1 on the season with Shohei Ohtani pitching and scored 15 combined runs in those three games.
Let’s dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Dodgers at Giants
- Date: Wednesday, April 22, 2026
- Time: 9:45 PM EST
- Site: Oracle Park
- City: San Francisco, CA
- Network/Streaming: MLB TV
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Dodgers at the Giants
The latest odds as of Wednesday:
- Moneyline: Los Angeles Dodgers (-207), San Francisco Giants (+169)
- Spread: Giants +1.5 (+104), Dodgers -1.5 (-126)
- Total: 8.0
Probable starting pitchers for Dodgers at Giants
- Wednesday’s pitching matchup (April 22): Shohei Ohtani vs. Tyler Mahle
- Dodgers: Shohei Ohtani
2026 stats: 18.0 IP, 2-0, 0.50 ERA, 0.72 WHIP, 18 Ks, 6 BB
2026 Stats: 18.2 IP, 0-3, 7.23 ERA, 1.93 WHIP, 21 Ks, 12 BB
Who’s Hot? Who’s Not!
- The Giants’ Luis Arraez is hitting .302 with 26 hits and 31 total bases over 86 at-bats
- The Giants’ Harrison Bader is hitting .115 with 6 hits and 17 strikeouts over 52 at-bats
- The Dodgers’ Andy Pages is hitting .366 with 30 hits and 49 total bases over 82 at-bats
- The Dodgers’ Alex Freeland is hitting .207 with 12 hits and 22 strikeouts over 58 at-bats
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Top betting trends & insights to know ahead of Dodgers at Giants
- The Giants are 11-9-3 ATS this season
- The Dodgers are 12-11 ATS this season
- The Giants are 10-10-3 to the Over this season
- The Dodgers are 12-11 to the Under this season
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Dodgers and the Giants
Rotoworld Bet Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Dodgers and the Giants.
- Moneyline: NBC Sports Bet is recommending a play on the Dodgers on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Dodgers at -1.5.
- Total: NBC Sports Bet is recommending a play on the Over on the Game Total of 8.0
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- Jay Croucher (@croucherJD)
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- Vaughn Dalzell (@VmoneySports)
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