Tonight is the second game of a three-game set between the White Sox (40-37) and the Guardians (41-38). Chicago pulled into a tie atop the American League’s Central Division last night with a 6-5 win over Cleveland.
Sam Antonacci rescued the Sox with a walk-off two-run single after the Chicago bullpen blew a 4-3 lead in the top half of the ninth. The Guardians rallied in the seventh scoring three times to tie the game at three apiece. Chicago retook the lead after the seventh inning stretch before imploding in the ninth. Anthony Kay started for the White Sox and threw six scoreless innings. Chris Murphy closed out the ninth for Chicago to earn the win. Cade Smith took the loss giving up two runs over 1.2 innings.
The Guardians have now lost three of their last four while the White Sox snapped a three-game losing streak.
Parker Messick takes the mound for Cleveland tonight. The right-hander owns a record of 7–3 with a 2.70 ERA, and 1.10 WHIP across 86.2 innings. He has struck out 91 while walking just 28. The rookie has allowed just eight home runs on the campaign which equates to slightly more than one every two outings. Taking the ball for Chicago is Sean Burke. The righty brings a 4–4 record, 3.89 ERA, and 1.22 WHIP over 81 innings with him to Rate Field tonight. Burke has fanned 81 hitters with 29 walks while allowing 10 homers.
Lets dive into tonight’s matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game Details and How to Watch: Guardians vs. White Sox
- Date: Tuesday, June 22, 2026
- Time: 7:40PM EST
- Site: Rate Field
- City: Chicago, IL
- Network/Streaming: MLB.TV, CLEGuardians.TV, CSN
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The Latest Odds: Guardians vs. White Sox
The latest odds as of Tuesday courtesy of DraftKings:
- Moneyline: Cleveland Guardians (-115), Chicago White Sox (-105)
- Spread: Guardians -1.5 (+153), White Sox +1.5 (-186)
- Total: 7.0 runs
Probable Starting Pitchers and their Stats: Guardians vs. White Sox for June 23
- Guardians: Parker Messick
Season Totals: 86.2 IP, 7-3, 2.70 ERA, 1.10 WHIP, 91K, 28 BB - White Sox: Sean Burke
Season Totals: 81.0 IP, 4-4, 3.89 ERA, 1.22 WHIP, 81K, 29 BB
Who’s Hot? Who’s Not! Guardians vs. White Sox
- Sam Antonacci has hit safely in 7 of his last 8 games (10-27)
- Colson Montgomery is 0-15 over his last 4 games
- Andrew Benintendi has been on base one time over his last 4 games
- Brayan Rocchio has hit safely in 4 of his last 5 games (8-21)
- Steven Kwan has 1 hit in his last 8 games (1-15) and 3 in his last 11 (3-25)
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Top Betting Trends & Insights: Guardians vs. White Sox
- The Guardians are 43-36 on the Run Line this season
- The White Sox are 44-33 on the Run Line this season
- The OVER has cashed 45 times in Chicago’s 77 games this season (45-30-2)
- The OVER has cashed 39 times in the Guardians’ 79 games this season (39-40)
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Expert picks & predictions: Guardians vs. White Sox
Rotoworld Bet Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for tonight’s game between the Guardians and the White Sox:
- Moneyline: Rotoworld Bet is recommending a play on the Guardians on the Moneyline.
- Spread: Rotoworld Bet is leaning towards a play on the Guardians on the Run Line.
- Total: Rotoworld Bet is leaning towards a play on the Game Total OVER 7.0
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