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Orioles vs. Red Sox Games 1 AND 2 prediction: Odds, recent stats, trends, and best bets on July 22

A rainout on Tuesday has set up a doubleheader today at Fenway Park between the Red Sox (51-48) and the Orioles (49-52). Boston takes the field in Game 1 riding a 14-game winning streak that has lifted them out of the cellar in the AL East and into the thick of the division and wild card races. They trail the Rays in the East by 6.5 games and now sit in the third and final wild card spot. Baltimore’s seven-game winning streak was snapped Monday, but it pulled them to within three games of the final wild card spot.

The opener features a pitching matchup that appears to favor Boston. Dean Kremer (1-2, 4.15 ERA) gets the ball for the O’s. In 26 innings this season, Kremer has posted a 4.15 ERA with 29 strikeouts and a strong 1.12 WHIP. The right-hander has served up nine home runs this season, though. While the Sox do not mash the ball, that is an unhealthy number. Kremer did not serve up a home run in his last outing. On July 17 in Houston he allowed two runs on four hits over four innings. Boston counters with rookie left-hander Jake Bennett (5-3, 2.35 ERA), who has been one of the club’s biggest surprises. Bennett owns a 0.88 WHIP and he has offered up just three home runs in 53.2 innings. Bennett’s most recent start came July 17 against Tampa Bay in which he threw six innings of one-hit, shutout ball.

Baltimore will hand the ball to its ace, Kyle Bradish (6-9, 3.61 ERA) in Game 2. Bradish’s last start was July 11 against Kansas City. He gave up two hits and one run over 6.2 innings. He has seen the Sox this season previously, dropping a 5-3 decision in which he surrendered four hits and three runs over five innings. Boston has yet to officially announce a starter at the time of publication. However, interim manager Chad Tracy indicated that left-hander Ranger Suárez (4-3, 3.15 ERA), currently on the injured list with a groin issue, is a candidate to return and start the nightcap.

The storyline of the day is simple: Boston is looking to extend one of the hottest streaks in baseball, while Baltimore hopes Bradish and Kremer can slow down a Red Sox club that has suddenly become a serious contender in the AL East.

Lets dive into the doubleheader and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game Details and How to Watch Game 1: Orioles vs. Red Sox

  • Date: Wednesday, July 22, 2026
  • Time: 1:35PM EST
  • Site: Fenway Park
  • City: Boston, MA
  • Network/Streaming: MLB.TV, MASN, NESN

Game Details and How to Watch Game 2: Orioles vs. Red Sox

  • Date: Wednesday, July 22, 2026
  • Time: 7:10PM EST
  • Site: Fenway Park
  • City: Boston, MA
  • Network/Streaming: MLB.TV, MASN, NESN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

The Latest Odds for Game 1: Orioles vs. Red Sox

As of Wednesday courtesy of DraftKings:

  • Moneyline: Baltimore Orioles (+135), Boston Red Sox (-163),
  • Spread: Orioles +1.5 (-149), Red Sox -1.5 (+124)
  • Total: 9.5 runs

The Latest Odds for Game 2: Orioles vs. Red Sox

As of Wednesday courtesy of DraftKings:

  • Moneyline: Baltimore Orioles (+114), Boston Red Sox (-137),
  • Spread: Orioles +1.5 (-181), Red Sox -1.5 (+149)
  • Total: 9.0 runs

Probable Starting Pitchers and their Stats: Orioles vs. Red Sox for Game 1 on July 22

  • Orioles: Dean Kremer
    Season Totals: 26.0 IP, 1-2, 4.15 ERA, 1.12 WHIP, 29K, 7 BB
  • Red Sox: Jake Bennett
    Season Totals: 53.2 IP, 5-3, 2.35 ERA, 0.88 WHIP, 38K, 9 BB

Probable Starting Pitchers and their Stats: Orioles vs. Red Sox for Game 2 on July 22

  • Orioles: Kyle Bradish
    Season Totals: 107.1 IP, 6-9, 3.61 ERA, 1.35 WHIP, 106K, 50 BB
  • Red Sox: Ranger Suarez (not announced as the starter but indications suggest)
    Season Totals: 91.1 IP, 4-3, 3.15 ERA, 1.16 WHIP, 97K, 26 BB

Who’s Hot? Who’s Not! Orioles vs. Red Sox

  • Willson Contreras is 2-4 in his career against Bradish with 2 HRs
  • Jarren Duran is 5-11 vs. Kremer in his career
  • Masataka Yoshida is 5-10 in his career against Kremer
  • Jarren Duran has K’d 5 times in 11 career ABs against Bradish
  • Jake Bennett has never faced the Orioles in his young career
  • Pete Alonso is 1-13 since the All-Star Break
  • Gunnar Henderson is 4-18 since the All-Star Break
  • Coby Mayo is 3-12 with 1 HR since the Break

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top Betting Trends & Insights: Orioles vs. Red Sox

  • The Orioles are 51-50 on the Run Line this season
  • The Red Sox are 47-52 on the Run Line this season
  • The OVER has cashed 53 times in Baltimore’s 101 games this season (53-45-3)
  • The OVER has cashed 45 times in Boston’s 99 games this season (45-50-4)

Guardians to face Rays on Sunday Leadoff

The Cleveland Guardians head to the Sunshine State to play the Tampa Bay Rays on Sunday Leadoff. Tune in at noon ET on Peacock and NBCSN.

Expert picks & predictions: Orioles vs. Red Sox

Rotoworld Bet Best Bet

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model for today’s day-night doubleheader between the Orioles and the Red Sox:

Orioles vs. Red Sox Game 1 Predictions

  • Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
  • Spread: Rotoworld Bet is recommending a play on the Red Sox on the Run Line.
  • Total: Rotoworld Bet is staying away from a play on the Game Total of 9.5.

Orioles vs. Red Sox Game 2 Predictions

  • Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
  • Spread: Rotoworld Bet is recommending a play on the Red Sox on the Run Line.
  • Total: Rotoworld Bet is leaning towards a play on the Game Total UNDER 9.0

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Trysta Krick (@Trysta_Krick)



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